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Design and Analysis of Cluster Randomization Trials in Health Research (Hodder Arnold Publication)
by Allan Donner, Neil Klar
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Design and Analysis of Cluster Randomization Trials In Current Issues in the Design of Cluster Randomization Trials Allan Donner PhD FRSC Department of Epidemiology and Biostatistics The University of Western Ontario London Canada Robarts Clinical Trials Robarts Research Institute London Canada What Are Cluster Randomization Trials analysis • CLUSTER RANDOMIZATION TRIALS Design and Analysis of Cluster Randomization Trials in Design and Analysis of Cluster Randomization Trials in Health Research Allan Donner and Neil Klar Design and Analysis of Cluster Randomization Trials in Health Research Allan Donner and Neil Klar practical and ethical concerns raised by cluster randomization Furthermore research into these issues is not confined to the How to design analyse and report cluster randomised How to design analyse and report cluster randomised trials in medicine and health services research Book · April 2014 with 86 Reads DOI 1010021 How to design efficient cluster randomised trials The BMJ Cluster randomised trials CRTs involve randomisation of groups clusters of individuals to control or intervention conditions1 The CRT design is commonly used to evaluate nondrug interventions such as policy and service delivery interventions Its use is likely to grow as we move towards the learning healthcare system2 and large simple trials3 Design and Analysis of Cluster Randomization Trials in Health Research Hodder Arnold Publication Design and Analysis of Cluster Randomization Trials in Health Research Hodder Arnold Publication Cluster Analysis In SPSS A Stepped Wedge Cluster Randomized Design Day 3 of TasP 2012 Design and Analysis of Cluster Randomization Trials in Download Citation on ResearchGate On Apr 1 2001 Terry N Flynn and others published Design and Analysis of Cluster Randomization Trials in Health Research Allan Donner and Neil Klar London Design and Analysis of Cluster Randomization Trials in 12 What is the impact of cluster randomization on the design and analysis of a trial 13 Quantifying the effect of clustering 14 Randomized versus nonrandomized comparisons 15 The unit of inference 16 Terminology what’s in a name 2 The historical development of cluster randomized trials 21 Randomized trials before 1950 Design and Analysis of Cluster Randomization Trials In Unit of Randomization vs Unit of Analysis A key property of cluster randomization trials is that inferences are frequently intended to apply at the individual level while randomization is at the cluster or group level Thus the unit of randomization may be different from the unit of analysis In this case the lack of independence among Pitfalls of and Controversies in Cluster Randomization Trials Cluster randomization trials in which intact groups of individuals are randomized to receive different interventions have been increasingly adopted by public health researchers over the past 2 decades after publication of a seminal article by Cornfield1 and the extensive methodological developments stimulated by this article The units of randomization for such trials are diverse including Analysis of cluster randomized trials in primary care a Despite the growing literature on the appropriate methods for the design and analysis of cluster randomized trials 1 2 those trials that account appropriately for clustering remain in the minority 3 4 5 Inappropriate analysis and poor reporting of such trials can lead to the presentation of inaccurate results and hence potentially
